$20.85: GlyNAC improved multiple age-related problems in adults

TLDR:

: A study investigated whether GlyNAC (a combination of glycine and N-acetylcysteine) supplementation can improve age-related problems in older adults, like oxidative stress, mitochondrial dysfunction, and insulin resistance. The study hypothesizes that the antioxidant glutathione (GSH) plays a role in these problems.

:

• 24 older adults were randomly assigned to receive either GlyNAC or a placebo for 16 weeks.
• 12 young adults received GlyNAC for 2 weeks.
• Researchers measured GSH levels, oxidative stress, mitochondrial function, inflammation, insulin resistance, physical function, and other aging markers before and after the supplementation periods.

:

• Older adults had lower GSH levels, increased oxidative stress and mitochondrial dysfunction, inflammation, insulin resistance and other aging hallmarks compared to young adults.
• GlyNAC supplementation in older adults improved these defects. The placebo did not.

: GlyNAC supplementation appears to be a safe and effective way to address multiple age-related problems and promote healthier aging.

More Specifics:

GlyNAC supplementation demonstrated significant benefits for mitochondrial health in older adults through multiple mechanisms, as shown in a 16-week randomized controlled trial127. Here's how it impacts mitochondrial function:

• : GlyNAC increased mitochondrial fatty-acid oxidation (MFO) by 78% in older adults, restoring levels comparable to younger adults13.
• : Mitochondrial glucose oxidation (MGO) decreased by 65%, correcting metabolic imbalances linked to aging1.

• : GlyNAC upregulated markers of mitochondrial biogenesis (e.g., PGC1α, SIRT1, TFAM) and energy metabolism enzymes (e.g., citrate synthase, ATP synthase)179.
• : The supplement promoted younger, more efficient mitochondria by enhancing mitophagy (damaged mitochondria removal) and biogenesis37.

• : Corrected age-related glutathione (GSH) deficiency, reducing oxidative stress that damages mitochondrial DNA and membranes157.
• : Lowered reactive oxygen species (ROS) production, protecting mitochondrial integrity59.

• : Addressed defective molecular regulation of mitochondrial dynamics (fusion/fission) and electron transport chain activity79.
• : Enhanced ATP production capacity and restored mitochondrial membrane potential79.

The study found these mitochondrial improvements correlated with better physical function (gait speed, muscle strength), reduced inflammation, and improved insulin sensitivity127. GlyNAC was well-tolerated with no serious adverse events reported, suggesting its potential as a safe intervention for age-related mitochondrial decline279.

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